CHOLESTEATOMA AND BONE DESTRUCTION
نویسندگان
چکیده
منابع مشابه
TLR4 drives the pathogenesis of acquired cholesteatoma by promoting local inflammation and bone destruction
Acquired cholesteatoma is a chronic inflammatory disease characterized by both hyperkeratinized squamous epithelial overgrowth and bone destruction. Toll-like receptor (TLR) activation and subsequent inflammatory cytokine production are closely associated with inflammatory bone disease. However, the expression and function of TLRs in cholesteatoma remain unclear.We observed inflammatory cell in...
متن کاملTREM-2 promotes acquired cholesteatoma-induced bone destruction by modulating TLR4 signaling pathway and osteoclasts activation
Triggering receptor expressed on myeloid cells (TREM) has been broadly studied in inflammatory disease. However, the expression and function of TREM-2 remain undiscovered in acquired cholesteatoma. The expression of TREM-2 was significantly higher in human acquired cholesteatoma than in normal skin from the external auditory canal, and its expression level was positively correlated with the sev...
متن کاملBone destruction in arthritis.
Rheumatoid arthritis (RA) is characterised by the presence of an inflammatory synovitis accompanied by destruction of joint cartilage and bone. Destruction of cartilage matrix results predominantly from the action of connective tissue proteinases released by RA synovial tissues, chondrocytes, and pannus tissue. Several lines of evidence in RA and in animal models of arthritis support a role for...
متن کاملBone destruction by Th17
Most cell junction proteins increase endothelial cell–cell adhesion. But junction adhesion molecule-C (JAM-C), despite its sticky name, loosens vascular endothelial cell connections, thus allowing increased blood vessel permeability. Increasing the permeability of small blood vessels is essential for new vessels to form and for leukocytes to escape the circulation and enter surrounding tissues ...
متن کاملCongenital cholesteatoma of the mastoid temporal bone.
OBJECTIVE Congenital mastoid cholesteatomas are rare lesions of the temporal bone. The clinical presentation of these lesions is variable, making them difficult to identify preoperatively. We evaluated our series of mastoid congenital cholesteatomas (CCs) in an effort to better define the clinical presentation, imaging characteristics, and surgical challenges specific to this lesion. STUDY DE...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nippon Jibiinkoka Gakkai Kaiho
سال: 1979
ISSN: 0030-6622,1883-0854
DOI: 10.3950/jibiinkoka.82.393